The probability of PCAD in subjects with low tertile ZAG levels was 2.48-fold higher than those with high tertile levels after adjusting for other confounders. Multiple regression analysis showed that PCAD was independently associated with serum ZAG levels ( B = −0.289, p = 0.002). 8.78 ± 1.89 μg/mL, p < 0.05), respectively, when compared with the controls. Results: Serum ZAG were significantly lower in the PCAD (8.03 ± 1.01 vs. Serum ZAG levels were determined by enzyme-linked immunosorbent assay (ELISA) method. In addition, 182 age and gender matched healthy controls were also enrolled. According to the degree of coronary artery stenosis, the number of 364 patients with PCAD (age <55 years in males and <65 years in females) and 126 age and gender matched patients without premature coronary artery disease (NPCAD) were recruited in our present study. Methods: A total of 3,364 patients who were undergone coronary angiography in Peking Union Medical College Hospital were screened. Objectives: To explore serum zinc-α2-glycoprotein (ZAG) changes in patients with or without premature coronary artery disease (PCAD) and its association with several cardiovascular risk factors. 2Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.1Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.Meijuan Liu 1 †, Huijuan Zhu 1 †, Tianshu Zhai 1, Hui Pan 1, Linjie Wang 1, Hongbo Yang 1, Kemin Yan 1, Yong Zeng 2 and Fengying Gong 1 *
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